CCT129202

CCT129202 Basic information
Product Name:CCT129202
Synonyms:CCT129202;2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide;2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(th;CCT129202 (CCT-129202;CS-407;CCT129202 USP/EP/BP;1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-
CAS:942947-93-5
MF:C23H25ClN8OS
MW:497.02
EINECS:
Product Categories:Inhibitor;Inhibitors
Mol File:942947-93-5.mol
CCT129202 Structure
CCT129202 Chemical Properties
density 1.427
storage temp. Store at -20°C
solubility DMSO : 1 mg/mL (2.01 mM; Need ultrasonic)
form Powder
pka9.26±0.50(Predicted)
Safety Information
MSDS Information
CCT129202 Usage And Synthesis
Biological ActivityCCT129202 is an ATP-competitive pan-Aurora inhibitor with IC50s of 0.042 μM, 0.198 μM and 0.227 μM for Aurora A, Aurora B and Aurora C, respectively, and has a weaker effect on FGFR3, GSK3β, PDGFRβ, etc.
in vivoCCT129202 at a dose of 100 mg/kg subcutaneously injected HCT116 colon xenografts in athymic mice, after 30 minutes, caused a ~50% decrease in histone H3 phosphorylation, and after 9 days of treatment, significantly inhibited tumor growth, compared with the control group , inhibited by 57.7%.
targetAurora A
CCT129202 Preparation Products And Raw materials
Barasertib (AZD1152-HQPA) Phenylsilane Linifanib (ABT-869) JNJ-7706621 Alisertib (MLN8237) N,N-Dimethylaniline Stattic 2,6-Dimethylaniline ZM 447439

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.