5,6,7,8-TETRAHYDRO-1-NAPHTHOL

5,6,7,8-TETRAHYDRO-1-NAPHTHOL Basic information
Uses Industrial Production
Product Name:5,6,7,8-TETRAHYDRO-1-NAPHTHOL
Synonyms:5,6,7,8-TETRAHYDRO-1-NAPHTHOL;1-Naphthol, 5,6,7,8-tetrahydro-;5,6,7,8-tetrahydro-1-naphthaleno;5,6,7,8-Tetrahydro-1-naphthalenol;5,6,7,8-Tetrahydro-alpha-naphthol;5,6,7,8-Tetrahydronaphthalenol;5-Hydroxytetralin;Tetrahydro-alpha-naphthol
CAS:529-35-1
MF:C10H12O
MW:148.2
EINECS:208-461-1
Product Categories:Organic Building Blocks;Oxygen Compounds;Phenols
Mol File:529-35-1.mol
5,6,7,8-TETRAHYDRO-1-NAPHTHOL Structure
5,6,7,8-TETRAHYDRO-1-NAPHTHOL Chemical Properties
Melting point 69-71 °C(lit.)
Boiling point 264-265 °C705 mm Hg(lit.)
density 1.0556
refractive index 1.5000 (estimate)
Fp 264-265°C/705mm
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pkapK1:10.28 (25°C)
form Solid
color Off-White to Pale Orange
BRN 1865081
InChIKeySCWNNOCLLOHZIG-UHFFFAOYSA-N
CAS DataBase Reference529-35-1(CAS DataBase Reference)
EPA Substance Registry System1-Naphthalenol, 5,6,7,8-tetrahydro- (529-35-1)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
HS Code 29071990
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
5,6,7,8-TETRAHYDRO-1-NAPHTHOL Usage And Synthesis
Uses

5,6,7,8-Tetrahydro-1-naphthol is a useful chemical intermediate, widely applied in organic synthesis and also used as a fuel additive.

Industrial Production

5,6,7,8-Tetrahydro-1-naphthol can be produced through partial reduction of aromatic ring of 1-naphthol by various homogeneous or heterogeneous catalytic hydrogenation methods.

Chemical Propertieswhite to slightly pink crystalline mass or
Uses5,6,7,8-Tetrahydro-1-naphthalenol was used as a reagent in the synthesis of phosphonamidate and phosphonodiamidate prodrugs of adefovir and tenofovir which are used in the treatment of HIV infections. Also used in the synthesis of tetrahydronaphthalene-1-ol derivatives which were found to be promising potent antitumor agents.
DefinitionChEBI: 5,6,7,8-tetrahydro-1-naphthol is 1-naphthol hydrogenated at C-5, -6, -7 and -8.
5,6,7,8-TETRAHYDRO-1-NAPHTHOL M-3-G HYDRATE Naloxone hydrochloride NALORPHINE HYDROCHLORIDE NORMORPHINE 4-HYDROXYESTRADIOL NALTRINDOLE HYDROCHLORIDE BETA-CHLORNALTREXAMINE DIHYDROCHLORIDE 1-ACETOXY-8-HYDROXY-1,4,4A,9A-TETRAHYDROANTHRAQUINONE 5-Methoxy-2-tetralone M-6-G TRIFLUOROACETATE-HYDRATE 2-amino-5,6-dihydroxytetralin 2-(N-phenethyl-N-propyl)amino-5-hydroxytetralin 1,2,3,4-TETRAHYDRO-1,5-NAPHTHALENEDIOL Minocycline NALBUPHINE HYDROCHLORIDE MORPHINIUM CHLORIDE NALOXONAZINE DIHYDROCHLORIDE

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