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Product Name: | 5,6,7,8-TETRAHYDRO-1-NAPHTHOL | Synonyms: | 5,6,7,8-TETRAHYDRO-1-NAPHTHOL;1-Naphthol, 5,6,7,8-tetrahydro-;5,6,7,8-tetrahydro-1-naphthaleno;5,6,7,8-Tetrahydro-1-naphthalenol;5,6,7,8-Tetrahydro-alpha-naphthol;5,6,7,8-Tetrahydronaphthalenol;5-Hydroxytetralin;Tetrahydro-alpha-naphthol | CAS: | 529-35-1 | MF: | C10H12O | MW: | 148.2 | EINECS: | 208-461-1 | Product Categories: | Organic Building Blocks;Oxygen Compounds;Phenols | Mol File: | 529-35-1.mol | |
| 5,6,7,8-TETRAHYDRO-1-NAPHTHOL Chemical Properties |
Melting point | 69-71 °C(lit.) | Boiling point | 264-265 °C705 mm Hg(lit.) | density | 1.0556 | refractive index | 1.5000 (estimate) | Fp | 264-265°C/705mm | storage temp. | Inert atmosphere,Room Temperature | solubility | Chloroform (Slightly), Methanol (Slightly) | pka | pK1:10.28 (25°C) | form | Solid | color | Off-White to Pale Orange | BRN | 1865081 | InChIKey | SCWNNOCLLOHZIG-UHFFFAOYSA-N | CAS DataBase Reference | 529-35-1(CAS DataBase Reference) | EPA Substance Registry System | 1-Naphthalenol, 5,6,7,8-tetrahydro- (529-35-1) |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26 | WGK Germany | 3 | HS Code | 29071990 |
| 5,6,7,8-TETRAHYDRO-1-NAPHTHOL Usage And Synthesis |
Uses | 5,6,7,8-Tetrahydro-1-naphthol is a useful chemical intermediate, widely applied in organic synthesis and also used as a fuel additive.
| Industrial Production | 5,6,7,8-Tetrahydro-1-naphthol can be produced through partial reduction of aromatic ring of 1-naphthol by various homogeneous or heterogeneous catalytic hydrogenation methods.
| Chemical Properties | white to slightly pink crystalline mass or | Uses | 5,6,7,8-Tetrahydro-1-naphthalenol was used as a reagent in the synthesis of phosphonamidate and phosphonodiamidate prodrugs of adefovir and tenofovir which are used in the treatment of HIV infections. Also used in the synthesis of tetrahydronaphthalene-1-ol derivatives which were found to be promising potent antitumor agents. | Definition | ChEBI: 5,6,7,8-tetrahydro-1-naphthol is 1-naphthol hydrogenated at C-5, -6, -7 and -8. |
| 5,6,7,8-TETRAHYDRO-1-NAPHTHOL Preparation Products And Raw materials |
Raw materials | Naphthalene, 1,2,3,4-tetrahydro-5-(2,2,2-trifluoroethoxy)--->Methanesulfonic acid, 1,1,1-trifluoro-, 5,6,7,8-tetrahydro-1-naphthalenyl ester-->1-bromotetralin-->1,2,3,4-Tetrahydro-1-naphthol-->1-Naphthol-->1-Tetralone | Preparation Products | 5,6,7,8-Tetrahydro-2-naphthol-->N-Methylcarbamic acid 5,6,7,8-tetrahydronaphthalen-1-yl ester-->1-(1-HYDROXY-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-ETHANONE |
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