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| Melting point | 214-217 °C | | storage temp. | -20°C | | solubility | DMF, DMSO, Hot methanol | | form | Off-white solid | | color | Whit to Off-White | | λmax | 240nm(H2O (pH 1))(lit.) | | BRN | 198460 | | CAS DataBase Reference | 5334-30-5(CAS DataBase Reference) |
| Chemical Properties | Whit to Off-White Solid | | Uses | Intermediate in the preparation of various enzymatic inhibitors | | Uses | The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. Several small molecule inhibitors of this signaling pathway have been developed as a therapeuptic strategy to abate abnormal Src kinase activity. PP3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2 . At concentrations as high as 10 μM, it does not prevent proliferation mediated by a stem cell factor/mast cell growth factor in hematopoietic and cancer cell lines.[Cayman Chemical] | | Definition | ChEBI: 1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine is a ring assembly and a member of pyrazoles. | | Biological Activity | Negative control for the src kinase inhibitor PP 2 (3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine ). Inhibits EGFR kinase (IC 50 = 2.7 μ M). | | storage | -20°C |
| | PP3 Preparation Products And Raw materials |
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