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N-DESMETHYL IMATINIB

N-DESMETHYL IMATINIB Basic information
Product Name:N-DESMETHYL IMATINIB
Synonyms:N-DESMETHYL GLEEVEC;N-DESMETHYL IMATINIB;Imatinib desmethyl (as formate);Imatinib Impurity 53;N-DESMETHYL IMATINIB USP/EP/BP;Benzamide, N-[2-methyl-5-[[4-[(4-methyl-1-piperazinyl)methyl]benzoyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-N-[4-(3-pyridinyl)-2-pyrimidinyl]-;N-DESMETHYL IMATINIB impurity B;N-4-((4-Methylpiperazin-1-yl)methyl)benzaldehyde
CAS:1356565-46-2
MF:C42H47N9O2
MW:709.88
EINECS:
Product Categories:
Mol File:Mol File
N-DESMETHYL IMATINIB Structure
N-DESMETHYL IMATINIB Chemical Properties
Melting point 180 - 190°C
density 1.248±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka13.20±0.70(Predicted)
form Solid
color Off-White to Light Yellow
Safety Information
MSDS Information
N-DESMETHYL IMATINIB Usage And Synthesis
UsesGleevec N-4-((4-Methylpiperazin-1-yl)methyl)benzaldehyde is an impurity of Gleevec (G407000), a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL).
UsesN-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
N-DESMETHYL IMATINIB Preparation Products And Raw materials
Imatinib Impurity 7 N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Imatinib Meta-methyl-piperazine Impurity IMatinib Para-diaMinoMethylbenzene Guanidine, N-(2-methyl-3-nitrophenyl)- N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine Imatinib (Piperidine)-N-oxide iMatinib related substance B N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib (Pyridine)-N-oxide Imatinib mesylate Imatinib impurity 12 Imatinib impurity 31 Guanidine, N-(2-methyl-6-nitrophenyl)- iMatinib related substance C Benzamide, 4-(dichloromethyl)-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- Guanidine, N-(2-methyl-4-nitrophenyl)-
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