(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole

(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole Basic information
Uses
Product Name:(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole
Synonyms:(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole;(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline;(4S)-4-(1,1-Dimethylethyl)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole;(S)-4-(tert-Butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole;(4S)-4-(1,1-Dimethylethyl)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole,99%e.e.;(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline,98%;(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline 97%;Oxazole, 4-(1,1-dimethylethyl)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-, (4S)-
CAS:148461-16-9
MF:C25H26NOP
MW:387.45
EINECS:
Product Categories:Chiral Phosphine;PHOX Series
Mol File:148461-16-9.mol
(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole Structure
(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole Chemical Properties
Melting point 111-116 °C
Boiling point 498.9±28.0 °C(Predicted)
storage temp. -20°C
pka4.44±0.70(Predicted)
optical activity[α]22/D -57.0°, c = 1 in chloroform
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29319090
MSDS Information
(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole Usage And Synthesis
Uses(S)-4-Tert-Butyl-2-(2-(Diphenylphosphino)Phenyl)-4,5-Dihydrooxazole (cas# 148461-16-9) is a useful research chemical.
Chemical PropertiesColorless solid
Uses(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline can be used as a ligand for enantioselective Heck reaction without any C=C double bond migration byproduct. It can also be used in a rhodium(I)-catalyzed enantioselective desymmetrization reaction of meso-3,5-dimethyl glutaric anhydride, to form substituted syn-deoxypolypropionate fragments in a single transformation.
General DescriptionThe product is a phosphinooxazoline (PHOX) ligand introduced by Pfaltz and coworkers. These non-symmetrical modular P,N-ligands are particularly useful in cases where double bond migration leads to undesired products or mixtures of isomers.
(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole Preparation Products And Raw materials
tert-Butyl methyl ether (4R)-4-(1,1-diMethylethyl)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-Oxazole Diphenyl-t-Butylsilanol (S)-4-benzyl-2-(quinolin-2-yl)-4,5-dihydrooxazole

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