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| | Methyl 3-amino-4-methylthiophene-2-carboxylate Basic information |
| | Methyl 3-amino-4-methylthiophene-2-carboxylate Chemical Properties |
| Melting point | 85-88 °C (lit.) | | Boiling point | 318.6±37.0 °C(Predicted) | | density | 1.264±0.06 g/cm3(Predicted) | | Fp | >100°C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 1.71±0.10(Predicted) | | form | Solid | | color | Pale Yellow | | Water Solubility | 1g/L at 35℃ | | BRN | 973196 | | InChIKey | YICRPERKKBDRSP-UHFFFAOYSA-N | | LogP | 1.28 | | CAS DataBase Reference | 85006-31-1(CAS DataBase Reference) | | NIST Chemistry Reference | Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25-22 | | WGK Germany | 2 | | Hazard Note | Irritant | | HS Code | 29349990 |
| | Methyl 3-amino-4-methylthiophene-2-carboxylate Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B. | | Application | methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.
The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield. | | Definition | ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid. |
| | Methyl 3-amino-4-methylthiophene-2-carboxylate Preparation Products And Raw materials |
| Raw materials | Ethanol-->Sodium hydride-->Hydroxylamine hydrochloride-->Methyl methacrylate-->Methyl thioglycolate-->Methyl 2-Methyl-3-Oxo-Tetrahydrothiophene-2-Carbonate-->4-METHYL-3-AMINO-2-(METHOXYCARBONYL)-4,5-DIHYDROTHIOPHENE | | Preparation Products | Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro--->METHYL 3-CHLORO-4-METHYLTHIOPHENE-2-CARBOXYLATE-->Methyl 3-dimethylamino-4-methylthiophene-2-carboxylate, 97%-->Thieno[3,2-d]pyriMidine, 2-chloro-7-Methyl-4-(4-Morpholinyl)--->7-(BROMOMETHYL)-2-CHLOROTHIENO[3,2-D]PYRIMIDINE-->7-Methylthieno[3,2-d]pyrimidine-2,4-diol-->tert-butyl 4-methylthiophen-3-ylcarbamate-->5-Chlorothieno[3,2-b]pyridine-3-carboxylic acid |
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