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| | Bismuth subnitrate Basic information |
| Product Name: | Bismuth subnitrate | | Synonyms: | Bismuth hydroxide nitrate oxide, Bi2O3 79% min;Bismuth(III) hydroxide nitrate, extra pure, Ph Eur, USP;BisMuth Subnitrate (AS);Bismuth Subnitrate (1.5 g) (AS);BISMUTH(III) NITRATE BASIC FOR ANALYSIS;BROMOTHYMOL BLUE SODIUM SALT INDICATOR W;Bismuth(Ⅲ) subnitrate;BisMuth(Ⅲ) nitrate basic | | CAS: | 1304-85-4 | | MF: | Bi5H9N4O22 | | MW: | 1461.99 | | EINECS: | 215-136-8 | | Product Categories: | Inorganics | | Mol File: | 1304-85-4.mol |  |
| | Bismuth subnitrate Chemical Properties |
| Melting point | 260°C | | density | 4.928 | | vapor pressure | 0Pa at 20℃ | | storage temp. | Store at +5°C to +30°C. | | solubility | Practically insoluble in water and in ethanol (96 per cent). It dissolves in mineral acids with decomposition. | | form | Powder/Solid | | color | White | | PH | 3.2 (50g/l, H2O, 20℃)(slurry) | | Water Solubility | Practically insoluble in water and alcohol. Soluble in dilute HNO{3} and HCl | | Sensitive | Hygroscopic | | Merck | 14,1284 | | Stability: | Stability Strong oxidizer - contact with combustible material may lead to fire. Incompatible with reducing agents, organic materials. | | CAS DataBase Reference | 1304-85-4(CAS DataBase Reference) | | EPA Substance Registry System | Bismuth hydroxide nitrate oxide (Bi5(OH)9(NO3)4O) (1304-85-4) |
| Hazard Codes | O,Xi | | Risk Statements | 8-36/37/38 | | Safety Statements | 17-26-36/37/39-36 | | RIDADR | UN 1477 5.1/PG 2 | | WGK Germany | 3 | | RTECS | EB2977000 | | F | 8 | | TSCA | Yes | | HS Code | 2834 29 80 | | HazardClass | 5.1 | | PackingGroup | II | | Hazardous Substances Data | 1304-85-4(Hazardous Substances Data) | | Toxicity | infant,LDLo,oral,1gm/kg (1000mg/kg),"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 134, 1969. |
| | Bismuth subnitrate Usage And Synthesis |
| Description | Bismuth subnitrate, also referred to as bismuth oxynitrate or bismuthyl nitrate, is a highly water-soluble crystalline compound that has been used as a treatment for duodenal ulcers and anti-diarrheic agent. The use of bismuth substrate as an active ingredient in over-the-counter antacids is approved by the FDA.
Bismuth Subnitrate is a basic salt that contains the equivalent of not less than 79.0 percent of bismuth trioxide (Bi2O3),calculated on the dried basis.It is both odorless and tasteless, and is used in bleaching and freckle creams, and hair dyes.
Bismuth subnitrate has been used to induce metallothionein in heart tissue and kidneys and to attenuate the toxicity of Adriamycin and cisplatin compounds, respectively.
| | Chemical Properties | White, heavy, Slightly hygroscopic powder | | Uses | manufacture of bismuth fluxes for enamels; in cosmetics. | | Uses | It is used pharmaceutically in wound dressing, ointment component and as an antiacid. In cosmetics it is used as a cosmetic white pigment. Used in Ceramic glazes and enamel fluxes. | | Uses | Bismuth subnitrate (BiNO3) is used in the cosmetics industry and to make ceramic and
enamel glazes. | | Brand name | Mammol (Abbott). | | Flammability and Explosibility | Nonflammable | | Pharmacology | Bismuth subnitrate acts as an antacid that exert protective effects on the gastric mucosa. In a double-blind endoscopically controlled study, bismuth substrate was demonstrated to be effective for symptomatic relief in duodenal ulcers. In the alcohol model of mucosal injury in the rat, bismuth substrate was shown to be cytoprotective. In a randomized clinical study consisting of patients with H. pylori-associated duodenal ulcer, adjunctive use of colloidal bismuth subnitrate in a short treatment regimen with omeprazole and clarithromycin resulted in improved eradication rate of H. pylori. | | Mode of action | Based on the findings of a clinical investigation in patients with duodenal ulcer disease and healthy volunteers receiving oral bismuth subnitrate tablets, the protective effects of bismuth subnitrate may be secondary to endogenous mucosal prostaglandin (PGE2) production, which is one of the deficient factors observed in peptic ulcer disease. Antacid neutralizing activity of bismuth subnitrate was demonstrated to have a significant postprandial effect on gastric pH. |
| | Bismuth subnitrate Preparation Products And Raw materials |
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