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4-Hydroxypiperidine

4-Hydroxypiperidine Basic information
Product Name:4-Hydroxypiperidine
Synonyms:PIPERIDIN-4-OL;4-PIPERIDINOL;4PPOL;4-HYDROXYPIPERIDINE;HYDROXYPIPERIDINE(4-);AURORA KA-1006;4-Hydroxypiperidine base;4-Hydroxypiperidine, 99+%
CAS:5382-16-1
MF:C5H11NO
MW:101.15
EINECS:226-373-1
Product Categories:Building Blocks;C5 to C7;Piperidines, Piperidones, Piperazines;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines;Alcohols and Derivatives;Amines and Anilines;Pyrans, Piperidines &Piperazines;Piperidine;Heterocyclic Compounds;NADIFLOXACIN;Pyrans, Piperidines & Piperazines
Mol File:5382-16-1.mol
4-Hydroxypiperidine Structure
4-Hydroxypiperidine Chemical Properties
Melting point 86-90 °C
Boiling point 108-114 °C/10 mmHg (lit.)
density 0.9903 (rough estimate)
vapor pressure 13Pa at 25℃
refractive index 1.4400 (estimate)
Fp 226 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka14.94±0.20(Predicted)
form Solid
color Off-White to pale Yellow
PH11.5-11.7 (H2O)Aqueous solution
Water Solubility soluble
Sensitive Hygroscopic
BRN 102738
InChIKeyHDOWRFHMPULYOA-UHFFFAOYSA-N
LogP-0.35 at 25℃
CAS DataBase Reference5382-16-1(CAS DataBase Reference)
NIST Chemistry Reference4-Hydroxypiperidine(5382-16-1)
Safety Information
Hazard Codes Xi,C
Risk Statements 36/37/38-34
Safety Statements 26-36-37/39-45-36/37/39-27
RIDADR 3263
WGK Germany 3
Hazard Note Irritant
HazardClass 8
PackingGroup III
HS Code 29333999
MSDS Information
ProviderLanguage
4-Hydroxypiperidine English
SigmaAldrich English
ACROS English
ALFA English
4-Hydroxypiperidine Usage And Synthesis
Chemical Propertiesyellow to yellow-orange wet solid
Uses4-Hydroxypiperidine is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.
Uses4-Hydroxypiperidine (4-Piperidinol) can be used in the synthesis of a highly potent and selective IP (PGI(2) receptor) agonist. It can also be used in the study of copper-catalyzed N- versus O-arylation.
General DescriptionThe molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor.
Flammability and ExplosibilityNotclassified
4-Hydroxypiperidine Preparation Products And Raw materials
Preparation Products2-(4-Hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide-->1-(5-(Hydroxymethyl)pyrimidin-2-yl)piperidin-4-ol-->1-(4-(Hydroxymethyl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-ol-->Ethyl 2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylate-->2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid-->2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxamide-->Loperamide-->Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->4-Chloro-N-methylpiperidine-->1-(2-FLUORO-4-NITROPHENYL)PIPERIDIN-4-OL-->1-(5-aminopyridin-2-yl)piperidin-4-ol-->1-(Benzyloxycarbonyl)-4-piperidinone-->4-Bromopiperidine hydrobromide-->1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL-->1-Boc-4-methanesulfonyloxypiperidine-->Ebastine-->1-Benzyl-4-hydroxypiperidine-->Methyl 4-hydroxypiperidine-1-carboxyl
3-HYDROXYPIPERIDINE 4-Hydroxypiperidine STRYCHNINE 4-(4-NITROBENZOYLOXY)-2,2,6,6-TETRAMETHYL-1-PIPERIDINYLOXY Homatropine Hydrobromide 10,11-Dimethoxystrychnine 4-(4'-CHLOROPHENYL)-4-HYDROXYPIPERIDINE,4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE,4-(CHLOROPHENYL)-4-HYDROXYPIPERIDINE Tropine Diphenoxylate 4-Piperidone hydrochloride hydrate 4-Cyanophenol 1-BOC-4-HYDROXYPIPERIDINE,1-(TERT-BUTOXYCARBONYL)-4-HYDROXYPIPERIDINE Haloperidol 4-ETHOXYFLUOROPHOSPHINYLOXY TEMPO lifibrate DROPERIDOL Diphenylpyraline Hydrochloride 1-BENZYL-4-HYDROXYPIPERIDINE
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