2,2-Diphenylacetic acid

2,2-Diphenylacetic acid Basic information
Product Name:2,2-Diphenylacetic acid
Synonyms:MONOCARBOXYMETHANEDIPHENYL;RARECHEM AL BO 1083;A-PHENYLPHENYLACETIC ACID;CARBOXYMETHANEDIPHENYL;DIPHENYLACETIC ACID;DIPHENYLMETHANE-A-CARBOXYLIC ACID;DIPHENYLMETHANE-ALPHA-CARBOXYLIC ACID;DIPHENYLMETHANECARBOXYLIC ACID
CAS:117-34-0
MF:C14H12O2
MW:212.24
EINECS:204-185-0
Product Categories:C13 to C42+;Pharmaceutical Intermediates;Aromatic Phenylacetic Acids and Derivatives;C13 to C42+Alphabetic;Carbonyl Compounds;Carboxylic Acids;D;DIO - DIZ
Mol File:117-34-0.mol
2,2-Diphenylacetic acid Structure
2,2-Diphenylacetic acid Chemical Properties
Melting point 147-149 °C(lit.)
Boiling point 195°C 25mm
density 1,257 g/cm3
vapor pressure 0.001Pa at 25℃
refractive index 1.6000 (estimate)
Fp 195°C/25mm
storage temp. Sealed in dry,Room Temperature
solubility 0.13g/l
pka3.94(at 25℃)
form Crystalline Powder
color White to creamy-white
PH3.8 (H2O, 20℃)(saturated solution)
Water Solubility Slightly soluble in water(0.13g/L).
Merck 14,3316
BRN 1910978
InChIKeyPYHXGXCGESYPCW-UHFFFAOYSA-N
LogP3.17 at 25℃
CAS DataBase Reference117-34-0(CAS DataBase Reference)
NIST Chemistry ReferenceBenzeneacetic acid, «alpha»-phenyl-(117-34-0)
EPA Substance Registry SystemBenzeneacetic acid, .alpha.-phenyl- (117-34-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/38-36/37/38
Safety Statements 24/25-36/37-26
WGK Germany 2
RTECS AH2515000
TSCA Yes
HazardClass IRRITANT
HS Code 29163900
Toxicitymouse,LD50,intraperitoneal,500mg/kg (500mg/kg),Farmaco, Edizione Scientifica. Vol. 13, Pg. 286, 1958.
MSDS Information
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2,2-Diphenylacetic acid English
SigmaAldrich English
ACROS English
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2,2-Diphenylacetic acid Usage And Synthesis
Chemical Propertieswhite to creamy-white crystalline powder
UsesKinetic resolution of racemic 1-heteroarylalkanols by asymmetric esterification using diphenylacetic acid with pivalic anhydride and a chiral acyl-transfer catalyst is described. Molecular crystal of acridine and diphenylacetic acid and its absolute asymmetric photodecarboxylating condensation generates chirality in a two-component. The activation parameters for the racemization of a series of ortho-alkyl-substituted diphenylacetic acids are determined.
DefinitionChEBI: A monocarboxylic acid that is acetic acid where the methyl hydrogens have been replaced by two phenyl groups respectively.
Synthesis Reference(s)Journal of the American Chemical Society, 69, p. 2325, 1947 DOI: 10.1021/ja01202a023
Synthetic Communications, 17, p. 1919, 1987 DOI: 10.1080/00397918708057804
Purification MethodsCrystallise the acid from *benzene, H2O or aqueous 50% EtOH. [Beilstein 9 H 673, 9 IV 2492.]
2,2-Diphenylacetic acid DIPHENYL-ACETIC ACID ETHYL ESTER Benzilic acid 2,2-DIPHENYLPROPIONIC ACID 9-Carboxyfluorene DIHYDROANTHRACENE-9,10-DICARBOXYLIC ACID 4,4'-DDA A,A-DIPHENYL-4-MORPHOLINEACETIC ACID, SODIUM SALT 2-(Dimethylamino)ethyl diphenylacetate hydrochloride 9-HYDROXYFLUORENE-9-CARBOXYLIC ACID Adiphenine hydrochloride 2-(DIMETHYLAMINO)ETHYL BENZILATE HYDROCHLORIDE Propantheline bromide ALPHA,ALPHA-DIPHENYL-GAMMA-BUTYROLACTONE 2,2-Diphenylglycine Triphenylacetic acid BUTYL BIS(DI-TERT-BUTYL-3,5-HYDROXY-4-PHENYL) ACETATE BELLADONNINE SULFATE

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