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| | NPS 2143 Basic information |
| Product Name: | NPS 2143 | | Synonyms: | 2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2143);2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile;NPS 2143 hydrochloride;2-Chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2;Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-;NPS 2143;SB-262470(NPS-2143) | | CAS: | 284035-33-2 | | MF: | C24H25ClN2O2 | | MW: | 408.92 | | EINECS: | | | Product Categories: | API intermediates | | Mol File: | 284035-33-2.mol |  |
| | NPS 2143 Chemical Properties |
| Boiling point | 608.4±55.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at RT | | solubility | ≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH | | form | Powder | | pka | 13.67±0.20(Predicted) |
| | NPS 2143 Usage And Synthesis |
| Uses | NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis. | | Biological Activity | nps-2143 is a novel and selective antagonist of casr (ca2+-sensing receptor) with the ec50 value of 4.27mm for [ca2+]o [1].calcilytics nps-2143 has been reported to diminish the sensitivity of the casr for [ca2+]o, resulting in an attenuated signal transduction in vitro and increased secretion of pth in vivo. in addition, the ec50 values of nps-2143 are 4.27, 1.56, 1.61, 2.46, 2.07 and 3.15mm for the wild-type casr, mutant casr (t151r, p221l, e767q, g830s, and a844t), respectively. apart from these, in hek 293t cells expressing casr, nps-2143 has been revealed to inhibit the [ca2+]o-induced cytosolic calcium signal in a concentration-dependent manner [1].. | | target | Ca(2+) receptor | | references | [1] letz s1, rus r, haag c, dörr hg, schnabel d, möhlig m, schulze e, frank-raue k, raue f, mayr b, schöfl c. novel activating mutations of the calcium-sensing receptor: the calcilytic nps-2143 mitigates excessive signal transduction of mutant receptors. j clin endocrinol metab. 2010 oct;95(10):e229-33. |
| | NPS 2143 Preparation Products And Raw materials |
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