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| | Dimethocaine Hydrochloride Basic information |
| Product Name: | Dimethocaine Hydrochloride | | Synonyms: | Larocaine hydrochloride;Dimethocaine hydrochloride;1-Propanol, 3-(diethylamino)-2,2-dimethyl-, 1-(4-aminobenzoate), hydrochloride (1:1);Larocaine HCl;3-(Diethylamino)-2,2-dimethyl-1-propanol 4-aminobenzoate hydrochloride;3-(diethylaMino)-2,2-diMethyl-1-Propanol 1-(4-aMinobenzoate) hydrochloride;1-AMinobenzoyl-2,2-diMethyl-3-diethylaMinopropanol Hydrochloride;3-DiethylaMino-2,2-diMethylpropyl p-aMinobenzoate Hydrochloride | | CAS: | 553-63-9 | | MF: | C16H26N2O2.ClH | | MW: | 314.854 | | EINECS: | 202-303-5 | | Product Categories: | Amines;Aromatics;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals | | Mol File: | 553-63-9.mol |  |
| | Dimethocaine Hydrochloride Chemical Properties |
| Melting point | 195-196℃ | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Water (Slightly) | | form | Solid | | color | White to Pale Beige | | InChI | InChI=1S/C16H26N2O2.ClH/c1-5-18(6-2)11-16(3,4)12-20-15(19)13-7-9-14(17)10-8-13;/h7-10H,5-6,11-12,17H2,1-4H3;1H | | InChIKey | WWTWKTDXBNHESE-UHFFFAOYSA-N | | SMILES | C1(=CC=C(N)C=C1)C(=O)OCC(C)(C)CN(CC)CC.Cl |
| Toxicity | MLD in mice, rabbits (g/kg): 0.30, 0.15 s.c.; 0.04, 0.015 i.v. (Hirschfelder, Bieter) |
| | Dimethocaine Hydrochloride Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | Dimethocaine Hydrochloride is a local anesthetic, because of its similarity in action to cocaine, has potential for abuse. This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1.2 μM comparable to that of cocaine (IC50 = 0.7 μM). As a result, dimethocaine dose-dependently substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys. This product is intended for forensic and research purposes.[Cayman Chemical]
| | Uses | A local anesthetic with stimulant properties. Studies have shown its potency to be about half that of Cocaine (C633500). | | Application | Dimethocaine Hydrochloride is a drug that belongs to the amide class. It has been shown to have significant effects on neuronal function in vivo, as well as on dopamine neurotransmission in vitro. It is also a substrate for uptake by the dopamine transporter and can inhibit locomotor activity in rats, suggesting it may be a potential therapeutic agent for the treatment of Parkinson's disease. It has been shown to be effective against cocaine addiction and can reduce angiogenic factors in vivo. The drug also interacts with other drugs, including synthetic cannabinoids and amphetamines, which are metabolized by CYP2B6 enzymes. These interactions may result in reduced efficacy of Dimethocaine Hydrochloride therapy. |
| | Dimethocaine Hydrochloride Preparation Products And Raw materials |
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