Ethyl potassium malonate

Ethyl potassium malonate Basic information

Product Name:	Ethyl potassium malonate
Synonyms:	AKOS 310;ETHYL POTASSIUM MALONATE;ETHYL MALONATE MONOPOTASSIUM SALT;ETHYL MONO POTASSIUM MALONATE;KEM;MALONIC ACID MONOETHYL ESTER POTASSIUM;MALONIC ACID MONOETHYL ESTER POTASSIUM SALT 98+%;Ethylpotassiummalonate,98%
CAS:	6148-64-7
MF:	C5H9KO4
MW:	172.22
EINECS:	228-156-7
Product Categories:	Pharmaceutical Intermediates;bc0001;6148-64-7
Mol File:	6148-64-7.mol

Ethyl potassium malonate Chemical Properties

Melting point	194 °C (dec.) (lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	Methanol (Slightly), Water (Slightly)
form	Powder or Cyrstals
color	White
PH	pH(50g/l, 25℃) : 5.5～8.0
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	3721682
InChIKey	WVUCPRGADMCTBN-UHFFFAOYSA-M
CAS DataBase Reference	6148-64-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	2
HS Code	29171910

MSDS Information

Provider	Language
Ethyl potassium malonate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Ethyl potassium malonate Usage And Synthesis

Chemical Properties	white crystals or powder
Uses	Ethyl potassium malonate (potassium ethyl malonate) may be used to generate (trimethylsilyl)ethyl malonate in situ, which can be acylated to prepare a variety of β-ketoesters or alkylidene malonates.
Uses	Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation. Further, it reacts with aryl nitriles to prepare beta-amino acrylates in the presence of zinc chloride and a catalytic amount of Hünig's base. In addition to this, it serves as an intermediate for the preparation of ethyl tert-butyl malonate.
General Description	Ethyl potassium malonate (potassium ethyl malonate) reacts with aryl nitriles in the presence of zinc chloride and a catalytic amount of Hünig′s base to yield β-amino acrylates. Ethyl potassium malonate is formed as an intermediate during the synthesis of ethyl tert-butyl malonate.

Ethyl potassium malonate Preparation Products And Raw materials

Raw materials

Ethyl hydrogen malonate-->Diethyl malonate

Preparation Products

Ethyl 2-chloropyrimidine-5-carboxylate-->2-MORPHOLIN-4-YL-PYRIMIDINE-5-CARBALDEHYDE-->ETHYL 2-HYDROXYPYRIMIDINE-5-CARBOXYLATE-->MONO-BENZYL MALONATE-->Ethyl 2,6-dichloro-5-fluoro-pyridine-3-acetoacetate-->3-CYCLOPROPYL-3-OXO-PROPIONIC ACID ETHYL ESTER-->ETHYL 3-METHOXYPHENYLACETATE-->Ethyl isobutyrylacetate-->3-OXO-3-(3-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER-->TERT-BUTYL 3-(ETHOXYCARBONYL)-2-OXOPROPYLCARBAMATE-->3-(4-TERT-BUTOXYCARBONYLAMINO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

Diisopropyl malonate Magnesium ethyl malonate Ethyl hydrogen malonate MONOMETHYL MALONATE Ethyl Succinyl Chloride Ethyl potassium malonate Potassium Propionate DI-POTASSIUM MALATE MONO-ETHYL SUCCINATE 3-tert-Butoxy-3-oxopropanoic acid PROPANEDIOIC ACID MONOPOTASSIUM SALT Potassium acetate hydrate Potassium 3-methoxy-3-oxopropanoate Diethyl methylmalonate propanedioate FORMIC ACID, POTASSIUM SALT (2:1) Diethyl ethylmalonate ETHYL MALONATE POTASSIUM SALT, [2-14C]

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