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| | Trimeprazine Basic information |
| Product Name: | Trimeprazine | | Synonyms: | n,n,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine;10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-;dl-Trimeprazine;Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]- (6CI, 8CI);Teralene;ALIMENAZINE;Trimeprazine (base and/or unspecified salts);alimemazine | | CAS: | 84-96-8 | | MF: | C18H22N2S | | MW: | 298.45 | | EINECS: | 201-577-3 | | Product Categories: | TEMARIL | | Mol File: | 84-96-8.mol |  |
| | Trimeprazine Chemical Properties |
| Melting point | 68°C | | Boiling point | bp0.3 150-175° | | density | 1.1163 (rough estimate) | | refractive index | 1.6000 (estimate) | | pka | pKa 9.00 (Uncertain) | | Water Solubility | 0.942 mg/L | | CAS DataBase Reference | 84-96-8 | | NIST Chemistry Reference | Trimeprazine(84-96-8) |
| | Trimeprazine Usage And Synthesis |
| Originator | Temaril,SKF,US,1958 | | Uses | antipruritic | | Uses | Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic
origin. | | Definition | ChEBI: Trimeprazine is a member of phenothiazines. | | Manufacturing Process | 95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6
grams) in xylene (140 cc) at a temperature of 130°C and the mixture is
heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in
xylene is then added over 50 minutes and heating with reflux is continued for
20 hours. After cooling, the mixture is treated with water (40 cc) and N
methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated
with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with
ether.
The extract is dried over potassium carbonate and evaporated and the residue
is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane
(12.6 grams) is collected, distilling between 150° and 175°C under a pressure
of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal
hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C. | | Brand name | Temaril (Allergan). | | Therapeutic Function | Antipruritic |
| | Trimeprazine Preparation Products And Raw materials |
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