3-Azetidinecarboxylic acid

3-Azetidinecarboxylic acid Basic information

Product Name:	3-Azetidinecarboxylic acid
Synonyms:	RARECHEM BK PT 0277;3-AZETIDINECARBOXYLIC ACID, 98+%;N-AZACYCLOPROPYLAMINO-3-CARBOXYLIC ACID;3-AZETIDINECARBOXYLIC ACID 98%;>Azetidine3-Carboxylicacid;Azetidine-3-carboxylic acid 96%;3-AZETIDINE-3-CARBOXYLIC ACID;cha-811
CAS:	36476-78-5
MF:	C4H7NO2
MW:	101.1
EINECS:	674-976-7
Product Categories:	Peptide;Amino Acids & Derivatives;Carboxylic Acids;Ring Systems;Pharmaceutical Raw Materials;Unusual amino acids;Heterocycles series;Miscellaneous;Carboxylic Acids;Amino Acids 13C, 2H, 15N;Azetidines;Simple 4-Membered Ring Compounds;Alicyclic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives;B-Amino
Mol File:	36476-78-5.mol

3-Azetidinecarboxylic acid Chemical Properties

Melting point	286 °C (dec.) (lit.)
Boiling point	189.47°C (rough estimate)
density	1.2245 (rough estimate)
refractive index	1.4540 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Water (Slightly)
form	Solid
pka	2.74±0.20(Predicted)
color	White to Off-White
Water Solubility	Soluble in water.
InChIKey	GFZWHAAOIVMHOI-UHFFFAOYSA-N
CAS DataBase Reference	36476-78-5(CAS DataBase Reference)
EPA Substance Registry System	3-Azetidinecarboxylic acid (36476-78-5)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-22-36-26
WGK Germany	3
RTECS	CM4310600
HazardClass	IRRITANT
HS Code	29349990
Toxicity	LD50 orl-rat: >5 g/kg FMCHA2 -,C65,91

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

3-Azetidinecarboxylic acid Usage And Synthesis

Chemical Properties	light yellow powder
Uses	3-Azetidinecarboxylic acid is a useful intermediate in the synthesis of polypeptides.
Uses	Azetidine and its derivatives are valuable compounds in pharmaceutical and agrochemical research.
Uses	Azetidine-3-carboxylic acid derivatives has potential biological and foldameric applications. Azetidine-3-carboxylic acid, a fairly strained molecule provides oxadiazoles in good yields. Azetidine-3-carboxylic acid is used as a chemical hybridising agent
Safety Profile	Low toxicity by ingestion and skincontact. When heated to decomposition it emits toxicvapors of NOx.

3-Azetidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Methanol-->Toluene-->Lithium Aluminum Hydride-->Palladium-->Acetonitrile-->Formaldehyde-->Diethyl malonate-->Tosyl chloride-->Epichlorohydrin-->Trifluoroacetic anhydride-->Copper(I) Cyanide-->Benzylamine-->N,N-Diisopropylethylamine-->Sodium bromide-->Ammonium formate-->Benzophenone

3-(3-CARBOXY-AZETIDIN-1-YL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (3R,4S)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]-1-azetidinecarboxylic acid 1,1-dimethylethyl ester AZETIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE 1-(2-fluorobenzoyl)-3-azetanecarboxylic acid [1,3']BIAZETIDINYL-3-CARBOXYLIC ACID METHYL ESTER 1-TERT-BUTYL-2-AZETIDINECARBOXYLIC ACID 1-(DICYCLOPROPYLMETHYL)-2-AZETIDINECARBOXYLIC ACID 1-(4-methylbenzoyl)-3-azetanecarboxylic acid 1-BENZYL-3-AZETIDINECARBOXYLIC ACID METHYL 1-(DIPHENYLMETHYL)AZETIDINE-3-CARBOXYLATE 1-BENZOYL-AZETIDINE-3-CARBOXYLIC ACID 4-(3-CARBOXY-AZETIDIN-1-YL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-(TETRAHYDRO-2-FURANYLMETHYL)-2-AZETIDINECARBOXYLIC ACID 1-(3-bromobenzoyl)-3-azetanecarboxylic acid [1,3']BIAZETIDINYL-3,1'-DICARBOXYLIC ACID 1'-TERT-BUTYL ESTER 1-(4-CHLORO-BENZYL)-AZETIDINE-3-CARBOXYLIC ACID 1-[4-(tert-butyl)benzoyl]-3-azetanecarboxylic acid 1-(1-BENZYL-PIPERIDIN-4-YL)-AZETIDINE-3-CARBOXYLIC ACID

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