retronecine

retronecine Basic information
Product Name:retronecine
Synonyms:(1R)-2,3,5,7aβ-Tetrahydro-1-hydroxy-1H-pyrrolizine-7-methanol;(1R)-2,3,5,7aβ-Tetrahydro-1α-hydroxy-1H-pyrrolizine-7-methanol;Retronecin;(1R,7aR)-2,3,5,7a-Tetrahydro-1-hydroxy-1H-pyrrolizine-7-methanol;1H-Pyrrolizine-7-methanol, 2,3,5,7a-tetrahydro-1-hydroxy-, (1R,7aR)-;(1R,7aR)-7-(Hydroxymethyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-ol
CAS:480-85-3
MF:C8H13NO2
MW:155.19
EINECS:
Product Categories:
Mol File:480-85-3.mol
retronecine Structure
retronecine Chemical Properties
Melting point 119-120°
alpha 20D +4.95° (c = 0.58 in alc)
Boiling point 80 °C(Press: 0.01 Torr)
density 1.29±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Ethanol (Slightly), Methanol (Slightly)
pka14.48±0.40(Predicted)
form neat
color Off-White to Light Brown
Safety Information
RIDADR 1544
WGK Germany 3
RTECS VH7175000
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data480-85-3(Hazardous Substances Data)
ToxicityLD50 i.v. in mice: 634.0 ±26.0 mg/kg (Harris)
MSDS Information
retronecine Usage And Synthesis
Uses(+)-Retronecine, is a Pyrrolizidine alkaloid (PA) , which is a hepatotoxic, that is, damaging to the liver. It is also tumorigenic. It can also be used as an intermediate for the synthesis of (+)-Lycopsamine (L487525), and (E325580).
DefinitionChEBI: Retronecine is a member of pyrrolizines.
retronecine Preparation Products And Raw materials
retronecine RETRORSINE ECHIMIDINE isatidine senecionine N-oxide anacrotine INTERMEDINE MONOCROTALINE riddelline trichodesmine JACOLINE SENECIONINE SENECIPHYLLIN fulvine LYCOPSAMINE (4AR,7R,8R,9R,12BR)-8,9-DIHYDROXY-7-ISOPROPYL-8,9-DIMETHYL-2,3,4,4A,8,9,12,12B-OCTAHYDRO-7H-5,11-DIOXA-2A-AZA-CYCLOUNDECA[CD]PENTALENE-6,10-DIONE indicine-N-oxide

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