2-Hydroxy-5-methyl-3-nitropyridine

2-Hydroxy-5-methyl-3-nitropyridine Basic information

Product Name:	2-Hydroxy-5-methyl-3-nitropyridine
Synonyms:	2-HYDROXY-5-METHYL-3-NITROPYRIDINE;2-HYDROXY-3-NITRO-5-METHYLPYRIDINE;2-HYDROXY-3-NITRO-5-PICOLINE;5-METHYL-3-NITRO-2(1H)-PYRIDINONE;3-(NITRO)-5-METHYLPYRIDIN-2-OL;5-Methyl-3-nitropyridin-2-ol;2-HYDROXY-3-NITRO-5-PICOLINE (2-HYDROXY-5-METHYL-3-NITROPYRIDINE);2-Hydroxy-5-methyl-3-nitropyridine 98%
CAS:	7464-14-4
MF:	C6H6N2O3
MW:	154.12
EINECS:
Product Categories:	Heterocyclic Building Blocks;blocks;NitroCompounds;Pyridines;Pyridine;C6;compounds of pyridine
Mol File:	7464-14-4.mol

2-Hydroxy-5-methyl-3-nitropyridine Chemical Properties

Melting point	179 °C (dec.) (lit.)
Boiling point	353.3±35.0 °C(Predicted)
density	1.24 g/mL at 25 °C(lit.)
storage temp.	2-8°C
solubility	soluble in Dimethylformamide
pka	8.78±0.10(Predicted)
form	powder to crystal
color	White to Yellow
CAS DataBase Reference	7464-14-4(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

2-Hydroxy-5-methyl-3-nitropyridine Usage And Synthesis

Uses	2-Hydroxy-5-methyl-3-nitropyridine may be used in the preparation of 2-chloro-5-methyl-3-nitropyridine via chlorination, using thionyl chloride. It may also be used is preparing proteasome inhibitors containing 5-methylpyridin-2(1H)-one moiety.

2-Hydroxy-5-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Sulfuric acid-->Nitric acid-->Sodium nitrite-->2-Amino-5-methylpyridine
Preparation Products	5-NITRONICOTINIC ACID-->2-BROMO-3-NITRO-5-METHYL PYRIDINE-->Pyridine, 5-methyl-2-(1-methylethoxy)-3-nitro-

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