benzofuran-6-carboxylic acid

benzofuran-6-carboxylic acid Basic information

Product Name:	benzofuran-6-carboxylic acid
Synonyms:	benzofuran-6-carboxylic acid;Lifitegrast Intermediate 1;Benzofuran-6-Caboxylic Acid;Lifitegrast Impurity 29;6-Benzofurancarboxylic acid;1-benzofuran-6-carboxylic acid;6-Benzofurancarboxylic acid / Lifitegrast intermediate;1-Piperazinecarboxylicacid,4-(2-bromoethyl)-,1,2-dimethylethylester
CAS:	77095-51-3
MF:	C9H6O3
MW:	162.14
EINECS:
Product Categories:	77095-51-3
Mol File:	77095-51-3.mol

benzofuran-6-carboxylic acid Chemical Properties

Melting point	>182°C (dec.)
Boiling point	325.6±15.0 °C(Predicted)
density	1.363
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.02±0.30(Predicted)
color	Dark Yellow to Very Dark Yellow
CAS DataBase Reference	77095-51-3

Safety Information

HS Code

2932990090

MSDS Information

benzofuran-6-carboxylic acid Usage And Synthesis

Physical Form	Solid
Uses	Benzofuran-6-carboxylic Acid is a reagent in the development of potent LFA-1/ICAM antagonist SAR 118 as an opthalmic solution for treating dry eyes. Preparation of piperidinylpyrimidine derivatives as inhibitors of HIV-1 LTR activation. It is also an important intermediate applied in organic synthesis.
Uses	Benzofuran-6-carboxylic Acid is a reagent in the development of potent LFA-1/ICAM antagonist SAR 118 as an opthalmic solution for treating dry eyes. Preparation of piperidinylpyrimidine derivatives as inhibitors of HIV-1 LTR activation.

benzofuran-6-carboxylic acid Preparation Products And Raw materials

Raw materials	Methyl 3-(allyloxy)benzoate-->Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate-->Methyl benzofuran-6-carboxylate-->BENZOFURAN-6-CARBONITRILE-->METHYL-4-IODO-3-HYDROXY BENZOATE-->Ethyl benzofuran-6-carboxylate-->1-BENZOFURAN-6-CARBALDEHYDE-->Methanol-->CARBON DIOXIDE-->6-Bromobenzofuran
Preparation Products	6-benzofuranmethanol

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