N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine

N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine Basic information

Product Name:	N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine
Synonyms:	BIS(TRIMETHYLSILYL)CYTOSINE;4-Pyrimidinamine, N-(trimethylsilyl)-2-[(trimethylsilyl)oxy]-;n-(trimethylsilyl)-2-[(trimethylsilyl)oxy]-4-pyrimidinamin;N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]-4-pyrimidinamine;Bis-(Trimethylsilyl) Cytosine (BSC);O2,N4-Bis(trimethylsilyl)cytosine;Pyrimidine, 2-(trimethylsiloxy)-4-[(trimethylsilyl)amino]-;N-(trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine
CAS:	18037-10-0
MF:	C10H21N3OSi2
MW:	255.46
EINECS:	241-945-0
Product Categories:
Mol File:	18037-10-0.mol

N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine Chemical Properties

Melting point	122°C
Boiling point	123 °C
density	0.994±0.06 g/cm3(Predicted)
Fp	65°C
pka	4.96±0.10(Predicted)
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
CAS DataBase Reference	18037-10-0(CAS DataBase Reference)
NIST Chemistry Reference	4-Pyrimidinamine, n-(trimethylsilyl)-2-[(trimethylsilyl)oxy]-(18037-10-0)
EPA Substance Registry System	4-Pyrimidinamine, N-(trimethylsilyl)-2-[(trimethylsilyl)oxy]- (18037-10-0)

Safety Information

TSCA

Yes

MSDS Information

N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine Usage And Synthesis

Uses	2,4-Bis(trimethylsilyl)cytosine is an intermediate used in the synthesis of 1’-Epi Gemcitabine Hydrochloride (E588510), which is an α-Anomer of Gemcitabine.

N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials	Bis(trimethylsilyl)trifluoroacetamide-->Hexamethyldisilazane-->Chlorotrimethylsilane-->N,O-Bis(trimethylsilyl)acetamide-->Cytosine
Preparation Products	4-Amino-1-3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone-->2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate

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