BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE]

BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] Basic information
Product Name:BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE]
Synonyms:BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE];(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid diphenylmethyl ester 4-oxide;(2S,5R)-Benzhydryl 3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide;(2S,5R)-3,3-dimethyl-7-oxo-4- oxide-4-Thia-1-azabicyclo[3.2. 0]heptane-2-carboxylic Acid Diphenylmethyl Ester;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, diphenylmethyl ester, 4-oxide, (2S,5R)-;Tazobactam Acid Impurity 24;Tazobactam Impurity 44;(2S,5R)-Benzhydryl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-
CAS:87579-78-0
MF:C21H21NO4S
MW:383.46
EINECS:
Product Categories:
Mol File:87579-78-0.mol
BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] Structure
BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] Chemical Properties
Boiling point 598.7±50.0 °C(Predicted)
density 1.37
storage temp. 2-8°C
solubility Dichloromethane
pka-3.44±0.60(Predicted)
form Solid
color Yellow
Safety Information
MSDS Information
BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] Usage And Synthesis
Uses(2S,5R)-3,3-dimethyl-7-oxo-4-oxide-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Diphenylmethyl Ester is an intermediate in the synthesis of Tazobactam Sodium Salt-13C2,15N1, which is the labelled analogue of Tazobactam Sodium Salt (T010100), which is a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.
BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] Preparation Products And Raw materials
(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Tadalafil EP IMpurity G Tadalafil Impurity 11 Tadalafil Impurity 39 Tadalafil Impurity 62 Tadalafil Impuirty 16 Tadalafil Impurity 25 (Mixture of Diastereomers) (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE (1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester Tadalafil iMpurity E Tadalafil Impuirty 7 Tadalafil Spiro-urethane Impurity (EP Impurity F) Tadalafil Impurity 14 Tadalafil Impurity 59 Tadalafil Impurity 47 Tadalafil Hydroxylactam Impurity (EP Impurity D) (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Tadalafil iMpurity B

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